The senator conceded he cannot make the changes alone, but said he wanted to outline a specific governing style to show the accomplishments it can achieve. He backed up his remarks with a Web ad featuring similar content.
"I'm not interested in partisanship that serves no other purpose than to gain a temporary advantage over our opponents. This mindless, paralyzing rancor must come to an end. We belong to different parties, not different countries," McCain said. "There is a time to campaign, and a time to govern. If I'm elected president, the era of the permanent campaign will end; the era of problem-solving will begin."
To the disdain of some fellow Republicans, the likely GOP nominee has worked with Democrats on legislation aimed at overhauling campaign finance regulations, redrafting immigration rules and regulations and implementing government spending controls.
While that has cultivated a maverick image for McCain, the Arizona senator has also been accused of exhibiting a nasty temper - swearing even at fellow lawmakers from his own party - and unabashed partisanship.
In particular, McCain has clashed with the leading Democratic presidential contender, Barack Obama. After tangling with the Illinois senator on lobbying reforms, McCain questioned Obama's integrity in a publicly released 2006 letter.
McCain wrote he had thought Obama's interest in ethics legislation "was genuine and admirable," before adding: "Thank you for disabusing me of such notions." He accused Obama of "partisan posturing."
In outlining other potential achievements of a first term in his speech, the 71-year-old McCain implicitly was suggesting he would seek a second term, an attempt to mute suggestions he would serve only four years after being the oldest president elected.
In particular, he sees a world in which the Taliban threat in Afghanistan has been greatly reduced.
He added: "The increase in actionable intelligence that the counterinsurgency produced led to the capture or death of Osama bin Laden, and his chief lieutenants. ... There still has not been a major terrorist attack in the United States since Sept. 11, 2001."
McCain also pledged to halt a Bush administration practice of enacting laws with accompanying signing statements that exempt the president from having to enforce parts he finds objectionable.