Chinese researchers design new bioprinting method for gastric wounds

BEIJING - Chinese researchers have designed a new way of treating gastric wounds by using a microrobot that can conduct in vivo bioprinting.

Gastric wall injury is a common problem in the digestive tract, which often requires drug therapy or invasive surgery. Bioprinting, a way of delivering new cells directly to the wound site to repair the tissue, offers a potentially very useful way to treat the problem.

Researchers from Tsinghua University put forward a new concept of "in situ in vivo bioprinting" and designed a microrobot that enters the body via an endoscope to carry out tissue repair.

They tested the microrobot and the delivery system with a biological model of a human stomach and an endoscope to mimic the insertion and bioprinting operation. They also carried out a bioprinting test in a cell culture dish to test how effective the device was at bioprinting viable cells and repairing wounds.

Tests showed that printed cells remained at high viability and steady proliferation, which indicated good biological function of the cells in printed tissue.

Xu Tao, one of the researchers, said the research verified the feasibility of this concept for treatment for gastric wall injuries and offered a potential application for a variety of wound treatments inside the body without the need for invasive surgeries.

"More work is needed, including reducing the size of the bioprinting platform and developing bioinks," Xu said.

Xu said the development of the system involves interdisciplinary research on biological manufacturing, 3D printing and mechanics.

"We hope the advances in the field of bioprinting can bring the potential for clinical sciences," Xu added.

The research was published in the journal Biofabrication.