The five were detained for their suspected roles in the blaze that erupted at the 25-storey Jianye Mansion on Sunday evening, according to police of the city's Yuexiu District.
The fire raged for over 11 hours before being put out at 6 a.m. Monday, enveloping the building in dazzling flames and clouds of black smoke, Xinhua reporters at the site said.
No casualties have been reported, yet the fire has again highlighted the limited ability of some cities to control fires in skyscrapers. Reporters said water from the fire engines only reached the tenth floor of the building.
A total of 58 fire engines and 350 fire fighters were mobilized to extinguish the fire.