The second part of the series, starring Johnny Depp, took more than any other movie at cinemas with million.
Second, with £45 million, was Daniel Craig's successful appearance as James Bond in Casino Royale.
The Da Vinci Code came third - taking just more than £30 million.
Overall, audiences at screens in the UK increased on last year. Ralph Ludemann from the Hollywood Reporter commented: "This proves there is an upward curve in the business and it bodes well for 2007."
The annual top 10 in full:
1. Pirates of the Caribbean: Dead Man's Chest (£52m)
2. Casino Royale (£44.6m)
3. The Da Vinci Code (£30.4m)
4. Ice Age 2: The Meltdown (£29.5m)
5. Borat (£23.7m)
6. X-Men: The Last Stand (£19.1m)
7. Cars (£16.3m)
8. Superman Returns (£16.1m)
9. Mission: Impossible III (£15.5m)
10. The Devil Wears Prada (£13.9m)