She was joined in multiple honors by veteran alt-country rockers Blue Rodeo, who won group for the year, best adult alternative album for "Small Miracles" and best video for "C'mon."
For Feist, the Junos cap a whirlwind year in which her album sold more than half a million copies in the United States and "1234" reached No. 4 on the Billboard list of Hot Digital Songs. She was also nominated for Grammy and Brit awards.
"This is better, not because I won a whole bunch of them -- thank you very much -- but it's just more comfortable," she said.
The awards for Blue Rodeo, the Toronto-based outfit led by Jim Cuddy and Greg Keelor, bring their Juno tally to 10 over a more than three-decade run.
The band is viewed as nearly as much a Canadian institution as Anne Murray, who also performed on Sunday. The 62-year-old pop songstress, who ruled the easy-listening airwaves in the 1970s and 1980s with such tunes as Snowbird and You Needed Me, was joined on stage by Jann Arden and Sarah Brightman.
Among other winners, modern-day crooner Michael Buble took home the Juno fan choice award, and later lamented good-naturedly to reporters about the attention Feist garners.
"I just kept kicking the shit out of myself for not writing "1234" I could have crooned it," he said before launching into a few bars a cappella.
Halifax, Nova Scotia-based indie band Wintersleep took home the Juno for new group, while Paul Brandt -- another Calgary artist -- won country recording of the year for "Risk."
Triumph, the 1970s-era power trio, was inducted into the Canadian Music Hall of Fame. The members said they are planning a reunion tour.