Tan Sri Rastam Mohd Isa is Chairman and Chief Executive of the Institute of Strategic and International Studies (ISIS) Malaysia.

Tan Sri Rastam is a retired diplomat. He was High Commissioner of Malaysia to Pakistan, Ambassador of Malaysia to Bosnia Herzegovina, Ambassador of Malaysia to the Republic of Indonesia and Permanent Representative of Malaysia to the United Nations in New York. He retired as Secretary General of the Ministry of Foreign Affairs on 2 September 2010.

Tan Sri Rastam is Chairman of the Malaysian National Committee for the Pacific Economic Cooperation Council (PECC) and Chairman of the Malaysian National Committee of the Council for Security Cooperation in the Asia Pacific (CSCAP).